Nongenetic Mechanisms of Drug Resistance in Melanoma

Mechanisms of Drug Resistance

Progress of research into the problem of resistance to antibiotics is held back by lack of knowledge of the biochemical mechanisms by which these drugs act. Fortunately, it is possible to study some of the mechanisms of drug resistance, even at a biophysical or biochemical level, without necessarily knowing very much about how the drug works—just as it is possible to study (at least at a biolog...

Antifungal drug resistance of yeasts in dermatology: mechanisms, epidemiology and clinical impact

Superficial dermatophytoses are among the most common infectious disease. The most commonly used antifungal categories reazoles, polyenes and echinocandins. Due to the limited number of available antifungal drugs, toxicity and the emergence of resistant (intrinsic or acquired) strains, antifungal strategy needs to be developed. Recently the researchers try to find alternative antifungal agents....

Dissecting resistance mechanisms in melanoma combination therapy

quiescent and physiological autophagy interact in response to therapies. Figure 2. A. Calibrating the model with in vitro data. B. Validating model predictions with in vitro combination therapy. Abstract— We present a compartment model that explains melanoma cell response and resistance to mono and combination therapies. Model parameters were estimated by utilizing an optimization algorithm to ...

Molecular mechanisms of drug resistance.

Mechanisms of cancer drug resistance.

The design of cancer chemotherapy has become increasingly sophisticated, yet there is no cancer treatment that is 100% effective against disseminated cancer. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic cell genetic differences in tumors, even those from the same tissue of origin. Frequently resistance is...